Faculty
Andrew S. Murkin
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Assistant Professor Phone: (716) 645-4249 Fax: (716) 645-6963 E-mail: amurkin@buffalo.edu |
Publication List:
- Liu, J.; *Murkin, A.S. Pre-Steady-State Kinetic Analysis of 1-Deoxy-D-xylulose-5-phosphate Reductoisomerase from Mycobacterium tuberculosis Reveals Partially Rate-Limiting Product Release by Parallel Pathways Biochemistry 2012, ASAP.
- Cassera, M.B.; Hazleton, K.Z.; Merino, E.F.; Obaldia III, N.; Ho, M.-C.; Murkin, A.S.; DePinto, R.; Gutierrez, J.A.; Almo, S.C.; Evans, G.B.;Babu, Y.S.; Schramm, V.L. Plasmodium falciparum Parasites are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model PLoS ONE 2011, 6, e26916.
- Silva, R.G.; Murkin, A.S.; Schramm, V.L. Femtosecond Dynamics Coupled to Chemical Barrier Crossing in a Born-Oppenheimer Enzyme Proc. Natl. Acad. Sci. USA 2011, 108, 18661.
- Silva, R.G.; Hirschi, J.S.; Ghanem, M.; Murkin, A.S.; Schramm, V.L. Arsenate and Phosphate as Nucleophiles at the Transition States of Human Purine Nucleoside Phosphorylase Biochemistry 2011, 50, 2701.
- Murkin, A.S.; Schramm, V.L. Purine Nucleoside Phosphorylases as Targets for Transition-State Analog Drug Design. In Drug Design: Structure- and Ligand-Based Approaches; Merz, K.M.; Reynolds, C.H.; Ringe, D., Eds.; Cambridge University Press: Cambridge, 2010; pp 215-247.
- Ghanem, M.*; Murkin, A.S.*; Schramm, V.L. Ribocation Transition State Capture and Rebound in Human Purine Nucleoside Phosphorylase Chem. Biol. 2009, 16, 971. (*Both authors contributed equally).
- Bettiol, E.; Samanovic, M.; Murkin, A.S.; Raper, J.; Buckner, F.; Rodriguez, A. Identification of Three Classes of Heteroaromatic Compounds with Activity Against Intracellular Trypanosoma cruzi by Chemical Library Screening PLoS Negl. Trop. Dis. 2009, 3, e384.
- Clinch, K.; Evans, G.B.; Furneaux, R.H.; Kelly, P.M.; Legentil, L.; Murkin, A.S.; Li, L.; Schramm, V.L.; Tyler, P.C.; Woolhouse, A.D. Third Generation Immucillins: Acyclic Immucillins as Inhibitors of Purine Nucleoside Phosphorylase J. Med. Chem. 2009, 52, 1126.
- Murkin, A.S.; Clinch, K.; Mason, J.M.; Tyler, P.C.; Schramm, V.L. Immucillins in Custom Catalytic-Site Cavities Bioorg. Med. Chem. Lett. 2008, 18, 5900 (Special issue invitation).
- Mason, J.M.; Murkin, A.S.; Li, L.; Schramm, V.L.; Gainsford, G.J.; Skelton, B.W. A Beta-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase J. Med. Chem. 2008, 51, 5880.
- Evans, G.B.; Furneaux, R.H.; Greatrex, B.; Murkin, A.S.; Schramm, V.L.; Tyler, P.C. Azetidine Based Transition State Analogue Inhibitors of N-Ribosyl Hydrolases and Phosphorylases J. Med. Chem. 2008, 51, 948.
- Murkin, A.S.; Tyler, P.C.; Schramm, V.L. Transition State Interactions Revealed in Purine Nucleoside Phosphorylase by Binding Isotope Effects J. Am. Chem. Soc. 2008, 130, 2166.
- Rinaldo-Matthis, A.; Murkin, A.S.; Ramagopal, U.; Clinch, K.; Mee, S.P.H.; Evans, G.B.; Tyler, P.C.; Furneaux, R.H.; Almo, S.C.; Schramm, V.L. L-Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase J. Am. Chem. Soc. 2008, 130, 842.
- Murkin, A.S.; Birck, M.R.; Rinaldo-Matthis, A.; Shi, W.; Taylor, E.A.; Almo, S.C.; Schramm, V.L. Neighboring Group Participation in the Transition State of Human Purine Nucleoside Phosphorylase Biochemistry 2007, 46, 5038.
- Deng, H.; Murkin, A.S.; Schramm, V.L. Phosphate Activation in the Ground State of Purine Nucleoside Phosphorylase J. Am. Chem. Soc. 2006, 128, 7765.
- Taylor Ringia, E.A.; Tyler, P.C.; Evans, G.B.; Furneaux, R.H.; Murkin, A.S.; Schramm, V.L. Transition State Analogue Discrimination by Related Purine Nucleoside Phosphorylases J. Am. Chem. Soc. 2006, 128, 7126.
- Murkin, A.S.; Chou, W.K.; Wakarchuk, W.W.; Tanner, M.E. Identification and Mechanism of a Bacterial Hydrolyzing UDP-N-Acetylglucosamine 2-Epimerase Biochemistry 2004, 43, 14290.
- Vann, W.F.; Daines, D.A.; Murkin, A.S.; Tanner, M.E.; Chaffin, D.O.; Rubens, C.E.; Vionnet, J.; Guerry, P.; Silver, R.P. The NeuC Protein of Escherichia coli K1 Is a Uridine Diphosphate N-Acetylglucosamine 2-Epimerase J. Bacteriol. 2004, 186, 706.
- Murkin, A.S.; Tanner M.E. Dehydroalanine-Based Inhibition of a Peptide Epimerase from Spider Venom J. Org. Chem. 2002, 67, 8389.
