Howard Tieckelmann Lecture Series
7th Annual Howard Tieckelmann Memorial Lecture
FRIDAY, APRIL 17, 2015
LECTURE - 4:00 PM in 225 Natural Sciences Complex, UB North Campus
- Detailed lecture schedule forthcoming - please check back
Professor William DeGrado, Department of Pharmaceutical Chemistry; Investigator, Cardiovascular Research Institute, University of California, San Francisco
"Analysis and Design of Membrane Proteins"
Abstract: This talk will begin with a brief overview of de novo protein design, in which proteins are designed from first principles. I will then discuss approaches to understand the principles of membrane protein assembly and function, with particular focus on the M2 proton channel from influenza A virus. The talk will conclude with the de novo design of a proton/Zn2+ antiporter.
Professor William DeGrado, Investigator, Cardiovascular Research Institute, Department of Pharmaceutical Chemistry, University of California, San Francisco
William (Bill) DeGrado’s work focuses on the design of peptides, proteins, and peptide mimetics. He received his Ph.D. in organic chemistry from the University of Chicago (1981). Bill was a member of DuPont Central Research and DuPont Merck Pharmaceutical Company from 1981 to 1996. In 1996, Bill moved to the Department of Biochemistry and Biophysics at the University of Pennsylvania, where he was a professor in the Department of Biochemistry & Biophysics and an adjunct member of the Chemistry Department. In 2011 he moved to the Department of Pharmaceutical Chemistry at the University of California San Francisco, where he is currently a professor and member of the Cardiovascular Research Institute. He is a member of the National Academy of Science, the American Academy of Arts and Sciences, and the National Academy of Inventors. He also was the scientific founder of PolyMedix, which was recently purchased by Cellceutix. Bill’s research interests include: de novo design of proteins and peptide design; peptide mimetics; structure, stability, and function of membrane proteins, including integrins and viral ion channels; design of biomimetic polymers; bioinorganic chemistry; and computational approaches to small molecule and protein design.